Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)

Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)

Neurotrophins and their receptors are key molecules in the development of thenervous system. Neurotrophin-3 binds preferentially to its high-affinity receptorNTRK3, which exists in two major isoforms in humans, the full-length kinaseactiveform (150 kDa) and a truncated non-catalytic form (50 kDa). T...

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Bibliographic Details
Main Author: Guidi, Mònica
Other Authors: Espinosa Parrilla, Yolanda
Format: Doctoral Thesis
Language:English
Published: Universitat Pompeu Fabra 2009
Subjects:
RISC complex
retinoic acid
renilla luciferase
real-time quantitative PCR
PTBP1
pri-miRNA
pre-miRNA
post-transcriptional regulation
piRNA
PicTar
pGL4.13
PCR
P-body
p75NTR
overexpression
NTRK3
NTRK2
NTRK1
non-coding RNAs
NGF
neurotrophin
neurotrophic signaling
neuronal differentiation
neurodevelopment
neuroblastoma
nervous system
mRNA
miRNA target prediction
miRNA profiling
miRNA mimic
miRNA microarray
miRNA inhibitor
miRanda
microRNA
microarray
luciferase assay
Ingenuity Pathway Analysis (IPA)
heLa cells
gene silencing
gene regulation
full-length isoform (FL-NTRK3)
firefly luciferase
ERK
disease
dicer
cancer development
BDNF
argonaute
alternative splicing
3'UTR
RNAhybrid
RT-PCR
SH-SY5Y cells
siRNA
standard error
synaptic plasticity
target validation
TargetScan
transfection
translational repression
TrkA
TrkB
TrkC
truncated isoform (TR-NTRK3)
tyrosine kinase (TK)
western blot
575
61
Online Access:http://hdl.handle.net/10803/7114
http://nbn-resolving.de/urn:isbn:9788469216972

Internet

http://hdl.handle.net/10803/7114
http://nbn-resolving.de/urn:isbn:9788469216972

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