Acquired resistance to the anti-EFGR monoclonal antibody cetuximab in colorectal cancer
EGFR is a transmembrane tyrosine kinase receptor from the HER family which, upon ligand stimulation, activates different signaling pathways involved in tumorogenesis. EGFR can be targeted by monoclonal antibodies, as cetuximab and panitumumab, which bind to EGFR preventing ligand stimulation of the...
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| Format: | Doctoral Thesis |
| Language: | English |
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Universitat Pompeu Fabra
2012
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| Online Access: | http://hdl.handle.net/10803/84183 |