NORMAL ABL1 IS A TUMOR SUPPRESSOR AND THERAPEUTIC TARGET IN BCR-ABL1-POSITIVE LEUKEMIAS
Biology === Ph.D. === BCR-ABL1 results from t(9;22)(q34;q11) reciprocal translocation resulting in BCR-ABL1 kinase expression, initiating chronic myeloid leukemia in chronic phase (CML-CP). At the initial stages of CML-CP both oncogenic BCR-ABL1 kinase and normal ABL1 kinase are expressed, however,...
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| Format: | Others |
| Language: | English |
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Temple University Libraries
2014
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| Online Access: | http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/239008 |