The Effects of Mechanical Loading on the Local Myofibrogenic Differentiation of Aortic Valve Interstitial Cells
Calcific aortic valve sclerosis is characterized by focal lesions in the valve leaflet. These lesions are rich in myofibroblasts that express α-SMA and cause fibrosis. Lesions tend to occur in regions of the leaflet that are subjected to large bending loads, suggesting a mechanobiological basis for...
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| Format: | Others |
| Language: | en_ca |
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2008
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| Online Access: | http://hdl.handle.net/1807/10442 |