Nuclear Factor (Erythroid 2-like) Factor 2 (Nrf2) as Cellular Protector in Bile Acid and Retinoid Toxicities

Nuclear Factor (Erythroid 2-like) Factor 2 (Nrf2) as Cellular Protector in Bile Acid and Retinoid Toxicities

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Exposure to toxic bile acids (BA) and retinoic acids (RA) is implicated in toxicities related to excessive oxidative stress. This thesis examined roles and mechanisms of the oxidative stress-responsive nuclear factor (erythroid 2-like) factor 2 (Nrf2) in adaptive cell defense against BA and RA toxi...

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Bibliographic Details
Main Author: Tan, Kah Poh
Other Authors: Ito, Shinya
Format: Others
Language:en_ca
Published: 2008
Subjects:
oxidative stress
glutathione
bile acid
Nrf2
retinoic acid
cholestasis
ATP-binding cassette transporters
mitogen activated protein kinase
multidrug resistance associated proteins
adaptive response
antioxidants
thioredoxin reductase
4-hydroxynonenal
lipid peroxidation
glutathione S-transferase
liver toxicity
antioxidant response element
cell defense
0383
Online Access:http://hdl.handle.net/1807/17287

Internet

http://hdl.handle.net/1807/17287

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