Synthesis of Highly Functionalized Tetrahydroisoquinolines by a Palladium-catalyzed Domino ortho-Alkylation/Heck Reaction Sequence and Diastereoselective Aryne Diels-Alder Reactions
We report a palladium-catalyzed, norbornene mediated synthesis of tetrahydroisoquinolines via a domino ortho-alkylation/Heck reaction sequence. The desired products are obtained in moderate to excellent yields starting from readily available aryl iodides. The reaction conditions can be extended to t...
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| Language: | en_ca |
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2009
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| Online Access: | http://hdl.handle.net/1807/17449 |