Disc1 Mutant Mice Subjected to Chronic Social Defeat Stress as a Model of Gene-Environment Interaction in Schizophrenia and Depression

Disc1 Mutant Mice Subjected to Chronic Social Defeat Stress as a Model of Gene-Environment Interaction in Schizophrenia and Depression

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Human genetic data suggests DISC1 (Disrupted-in-schizophrenia 1) is a susceptibility gene for schizophrenia and depression. Disc1 Q31L-/- mutants show depression-like behaviour and Disc1 L100P-/- mutants schizophrenia-like behaviour. Heterozygous mutants show an intermediate phenotype. In a gene-env...

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Bibliographic Details
Main Author: Haque, F. Nipa
Other Authors: Wong, Albert Hung Choy
Language:en_ca
Published: 2009
Subjects:
gene-environment interaction
social defeat
Disc1 mutant mice
schizophrenia
depression
animal model
disrupted-in-schizophrenia 1 (Disc1)
brain-derived neurotrophic factor (Bdnf)
phosphodiesterase 4b (Pde4b)
valproate
histone deacetylase (HDAC)
epigenetics
Q31L
L100P
0317
0384
0347
Online Access:http://hdl.handle.net/1807/18335

Internet

http://hdl.handle.net/1807/18335

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