Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation
B cells produce a diverse array of antibody specificities that are of low affinity during the initial phase of a humoral immune response. However, somatic hypermutation of the rearranged V region in the immunoglobulin locus generates new antibody affinities, accompanied by the selection of B cells t...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_ca |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1807/24345 |