The Effects of Purine Nucleoside Phosphorylase (PNP) Deficiency on Thymocyte Development
PNP is a crucial enzyme in purine metabolism, and its inherited defects result in severe T-lineage immune deficiency in humans. I hypothesized that PNP deficiency disrupts the development of late CD4-CD8- double negative (DN) thymocytes and induces mitochondrial-mediated apoptosis of CD4+CD8+ double...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/24616 |