The Role and Regulation of Factor Inhibiting HIF (FIH) in Normal and Pathological Human Placentae
Factor inhibiting HIF (FIH) negatively regulates hypoxia inducible factor-1 (HIF-1) transcriptional activity, selectively controlling certain HIF-1 target genes, such as vascular endothelial growth factor (VEGF) and prolyl hydroxylase domain 3 (PHD3), but not others. PHD3 and VEGF are important for...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/24624 |