The Role of the p53 Tumour Suppressor Protein in Relation to the Sensing of Ionizing Radiation-induced DNA Double-strand Breaks

The Role of the p53 Tumour Suppressor Protein in Relation to the Sensing of Ionizing Radiation-induced DNA Double-strand Breaks

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Our cells are constantly dealing with DNA damage generated by endogenous cellular activity (e.g. DNA replication) and exogenous agents (e.g. ultraviolet and ionizing radiation (IR)). The cellular stress response to DNA damage requires strict co-ordination between cell cycle checkpoint control and DN...

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Bibliographic Details
Main Author: Al Rashid, Shahnaz Tahihra
Other Authors: Bristow, Robert
Language:en_ca
Published: 2010
Subjects:
p53
Ionizing Radiation
ATM
53BP1
Cancer
Cell cycle
DNA damage
DNA repair
0760
Online Access:http://hdl.handle.net/1807/26447

Internet

http://hdl.handle.net/1807/26447

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