Elevated Intracellular Ca2+ Alters Mitochondrial Protein Import and the Accumulation of Intramitochondrial Proteins in Neurons
Most (99%) mitochondrial proteins are nuclear-encoded and must be imported into mitochondria. Deficits in mitochondrial protein import (MPI) affect mitochondrial function and can cause neurodegenerative diseases. I hypothesized that MPI was regulated by iCa2+. In differentiated PC12 cells, treatment...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/29535 |