Characterization of APLF in Non-homologous End-joining
APLF (Aprataxin and Polynucleotide kinase-Like Factor), a novel protein with a forkhead-associated (FHA) domain and two poly(ADP-ribose)-binding zinc fingers (PBZ), interacts with core non-homologous end-joining (NHEJ) repair factors, Ku and XRCC4-DNA ligase IV, and facilitates NHEJ. However, how AP...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/29632 |