The Role of ShcA Phosphotyrosine Signaling in the Myocardium
Tyrosine kinases (TK) are important for cardiac function, but their downstream targets in the adult heart have yet to be established. The ShcA docking protein binds specific phosphotyrosine (pTyr) sites on activated TKs through its N-terminal PTB and C-terminal SH2 domains and stimulates downstream...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/29899 |