Synthesis and Structural Studies of Oligoproline Macrocycles
Due to inherent rigidity of oligoproline peptides, forcing the C- and N-terminus in proximity for cyclization can be of significant challenge. To address this issue, a cyclization condition involing the help of amphoteric aziridine aldehydes has been developed. This one step cyclization protocol gen...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/31317 |