Probing the Mechanism of Correction in ΔF508-CFTR
Cystic Fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which cause loss function of the CFTR channel on the apical surface of epithelial cells. ΔF508-CFTR, the major mutation in patients, is misfolded, retained in the endoplasmic reticulum...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/31654 |