In situ Proximity Ligation-based Analysis Reveals Aberrant Dimerization and Activation of Epidermal Growth Factor Receptors Prevalent in Glioblastoma Multiforme
Aberrations in Epidermal Growth Factor Receptor (EGFR/ErbB1) signalling are the most common oncogenic stimuli in human glioblastoma multiforme (GBM). Interactions between mutant and wildtype ErbB family members in GBMs are of biological and potential therapeutic importance. In this thesis, we descri...
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Language: | en_ca |
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2011
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Online Access: | http://hdl.handle.net/1807/31755 |