Assessment of Missense Alterations in MLH1 and their Pathogenic Significance
Germline mutations in mismatch repair genes predispose individuals to Lynch Syndrome, the most common colorectal cancer predisposition syndrome. MLH1 is a key mismatch repair gene that is mutated in Lynch syndrome and about a third of the genetic alterations identified in MLH1 are missense variants...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/32048 |