NMDA Receptor Silencing is Mediated by Calcium Release from the Mitochondria via the Permeability Transition Pore in Anoxia-tolerant Turtle Neurons
Mammalian neurons are anoxia-sensitive and rapidly undergo excitotoxic cell death when deprived of oxygen, mediated largely by calcium entry through N-methyl-D-aspartate receptors (NMDARs). This does not occur in neurons of the anoxia-tolerant western painted turtle, where a decrease in NMDAR curren...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/33238 |