Identification of Germline Alterations in the Mad-homology 2 (MH2) Domain of SMAD3 and SMAD4 In Breast Cancer Susceptibility
A feature of neoplastic cells is that mutations in the key intermediates of TGF-β signaling contribute to the loss of sensitivity to its anti-tumor effects. The role of SMAD3 and SMAD4 germline mutations in breast cancer predisposition is currently unclear. To address this, mutation analysis of the...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/33713 |