Characterization of the Roles of TopoIIIα-RMI1 in Maintaining Genome Integrity
Bloom syndrome is a rare autosomal recessive disorder that is caused by mutations in the BLM gene. BLM associates with TopoIIIα and RMI1 to form a complex that is essential to maintain genome integrity. This complex catalyzes a dissolution reaction that resolves recombination intermediates contain...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/34975 |