Glycemic Index, Oxidized LDL, and CHD Risk

• Main Author: Mirrahimi, Arash
• Other Authors: Jenkins, David J. A.
• Language: en_ca
• Published: 2012
• Subjects: Glycemic Index; CHD; Oxidative Damage; Heart Disease; 0475
• Online Access: http://hdl.handle.net/1807/35523

The aim was to determine whether the dietary glycemic index (GI) related to coronary heart disease (CHD) risk and whether oxidized LDL could explain this relation. Nine prospective cohorts of GI or glycemic load (GL) associations were pooled in a meta-analysis and showed an increased risk of CHD for high GI (near significant at RR=1.13, 95%CI; 1.00-1.26) and GL diets (significant at RR=1.40, 95%CI; 1.17-1.68), both with significant evidence of heterogeneity (P<0.07). Sera from 151 type 2 diabetics who completed a 6-month trial of a low GI diet demonstrated no treatment difference in measures of oxidative damage. However, when data from both treatments were pooled, oxidized LDL as a marker of CHD risk inversely related to low GI carbohydrate intake. We conclude that GI and GL relate to CHD and oxidative damage to LDL may explain part of this association.