The Role of Hedgehog-Gli Pathway Regulators in Skin Development and Tumorigenesis
Proper control of Hedgehog (Hh) signaling is critical for hair follicle morphogenesis and ectopic Hh pathway activity is a hallmark of basal cell carcinoma (BCC), the most common type of skin cancer. Mutations in Hh pathway components such as the Hh-binding receptor PATCHED1 (PTCH1) are frequently f...
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| Language: | en_ca |
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2013
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| Online Access: | http://hdl.handle.net/1807/35881 |