Molecular Mechanisms of Medulloblastoma Formation: Tumor Suppressor Functions of Hedgehog Pathway Components
Hedgehog (Hh) signaling is essential for embryonic development and adult homeostasis. Aberrant pathway activity can result in various developmental disorders and cancers. The Hh receptor Patched1 (Ptc1) is a negative regulator of the pathway and acts as a tumor suppressor. Our lab and others have...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/42608 |