Preclinical Modeling of Treatment-induced Impulsivity in Parkinson's Disease

Preclinical Modeling of Treatment-induced Impulsivity in Parkinson's Disease

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Dopamine agonist therapy and deep brain stimulation (DBS) are both linked to increased impulsivity in Parkinson’s disease (PD), but the underlying mechanisms remain unclear. We trained intact and PD-like rats on a rat gambling task (rGT) measuring impulsive choice and premature responding. Animals...

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Bibliographic Details
Main Author: Aleksandrova, Lily R
Other Authors: Nobrega, José
Language:en_ca
Published: 2013
Subjects:
impulsivity
gambling
deep brain stimulation (DBS)
Parkinson's disease
pramipexole
6-OHDA lesions
rat gambling task (rGT)
dopamine
basal ganglia
premature responding
DBS amplitude
subthalamic nucleus (STN)
entopeduncular nucleus (EPN)
impulsive choice
0419
0317
Online Access:http://hdl.handle.net/1807/42665

Internet

http://hdl.handle.net/1807/42665

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