Repair of CFTR Defects Caused By Cystic Fibrosis Mutations
Cystic fibrosis is caused primarily by deletion of Phe508. An exciting discovery was that CFTR’s sister protein, the P-glycoprotein (P-gp) containing the equivalent mutation (ΔY490), could be repaired by a drug-rescue approach. Drug substrates showed specificity, and their mechanism involves direct...
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| Language: | en_ca |
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2013
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| Online Access: | http://hdl.handle.net/1807/42927 |