Organizing the Ubiquitin-dependent Response to DNA Double-Strand Breaks

Organizing the Ubiquitin-dependent Response to DNA Double-Strand Breaks

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DNA double-strand breaks (DSBs) are highly cytolethal DNA lesions. To protect genomic integrity and ensure cellular homeostasis, cells initiate a complex signaling-based response that activates cell cycle checkpoints, coordinates DNA repair, regulates gene expression and, if necessary, induces apopt...

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Bibliographic Details
Main Author: Panier, Stephanie
Other Authors: Durocher, Daniel
Language:en_ca
Published: 2013
Subjects:
DNA double-strand breaks
ubiquitylation
DNA damage response
chromatin
Molecular
Cell
Online Access:http://hdl.handle.net/1807/43705

Internet

http://hdl.handle.net/1807/43705

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