1. Syntheses and Opioid Activity of Spiro[benzofuran-3(2H),4’-piperidines] : A Conformation-activity Study and Novel Synthesis of Isoneopine : A Formal Total Synthesis of Morphine

博士 === 國立臺灣大學 === 藥學研究所 === 88 === Approaches based on simplification of the pentacyclic morphine skeleton towards the discovery of novel analgesics have been adopted by generations of medicinal chemists. However, the tricyclic spiro[benzofuran-3(2H),4’-piperidines], morphine ANO fragments, have nev...

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Bibliographic Details
Main Authors: Jing- Ping Liou, 劉景平
Other Authors: Cheng Chen-Yu
Format: Others
Language:zh-TW
Published: 2000
Online Access:http://ndltd.ncl.edu.tw/handle/61170371995587220133