Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents
碩士 === 高雄醫學大學 === 藥學研究所 === 89 === The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), a family of potent DNA-binding antitumor antibiotics, are produced by Streptomyces species. These drugs react covalently with DNA to form a N2-guanine adduct that lies within the minor groove of DNA. DC-81 i...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2001
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| Online Access: | http://ndltd.ncl.edu.tw/handle/62092090806010682902 |