Effect of Dehulled Adlay Added to Mung Bean on Lipid and Carbohydrate Metabolism in STZ-induced Diabetic Rats

• Main Authors: Yi-Hsuan Chiang, 江怡萱
• Other Authors: Chiang, Meng-Tsan
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/57108476453359182254

碩士 === 國立海洋大學 === 食品科學系 === 89 === Abstract The aim of this study was to investigate the effect dehulled adlay and mung bean in streptozocin (STZ) — induced diabetic rats. In experiment I was to evaluate the dehulled adlay starch and mung bean starch, characterized by different glycemic indices, on glucose and insulin response in normal and diabetic rats. The α- amylase digestibility was higher for dehulled adlay starch than that of the corn starch and mung bean starch. The glycemic index of the dehulled adlay starch was higher than that of the corn starch and mung bean starch when measured in vivo in three group of normal rats. In a subsequent study, normal and diabetic male Wistar rats was assessed by oral glucose tolerance test (OGTT) and added to mung bean extract. We found serum glucose responses were significantly lower in rats received mung besn extract in either normal or diabetic rats. In experiment II was to compare the effects of dehulled adlay added to mung bean on lipid and carbohydrate metabolism in diabetic rats. Male Wistar rats were used as experiment animal model and were made diabetic status by intravenous injection of 60 mg per kg of streptozotocin. The experiment laster four weeks and divided into three groups: (1) corn starch (2) dehulled adlay (3) dehulled adlay+ mung bean. The results showed that diabetic rats fed dehuller adlay groups had significantly heavier body weight, adipose tissue weight and relative adipose weight, but when added to mung bean, the difference was not significant with corn starch group. In addition, dehulled adlay decreased plasma total cholesterol levels, LDL-C and VLDL-C in diabetic rats. Added to mung bean however, the difference was not significant compared to corn starch diet. After fed dehulled adlay added to mung bean for four weeks, had significantly risen plasma triglyceride, VLDL-TG. Although dehulled adlay diet were not influence on plasma glucose levels, and mung bean increased significantly plasma glucose and phospholipid levels. In the other hand, dehulled adlay groups had markedly decreased plasma, liver, and kidney TBARS levers, whereas added to mung bean were higher. Especially, dehulled adlay added to mung bean diet increased significantly lipid peroxidation and antioxidative enzyme, glutathione peroxiadase (GSH Px), in diabetic rats.