Antioxidant and Antiinflammatory Effects of Glycyrrihizin on STZ-induced Diabetic Mice

• Main Authors: Yong-Ning, 鄭詠寧
• Other Authors: 劉德中
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/22207749044535679954

碩士 === 中山醫學大學 === 營養學研究所 === 96 === Liquorice root was well known for its antiinflammatory and antioxidative functions mainly came from the major component, glycyrrhizin. In our study, 0.5 g / l or 1 g / l of glycyrrhizin were added into drinking water of STZ-induced diabetic mice. After 4- week treatment, mice were sacrificed and then serum samples , homogenized kidney and spleen tissues were analyzed. The data showed increased serum insulin level and decreased blood glucose in diabetic mice after drinking glycyrrhizin water (p<0.05). TNF-α level in spleen tissue and IL-6 level in kidney tissue were decreased in diabetic mice with glycyrrhizin intake; however, only 1 g / l glycyrrhizin had significant effect (p < 0.05). MDA level in kidney tissue of diabetic mice were reduced dose-dependently with glycyrrhizin intake (p < 0.05), SOD enzyme activity in diabetic mice recovered to normal status after glycyrrhizin intake (p<0.05). These results indicated the oxidative stress were decreased in the diabetic mice with glycyrrhizin intake. Fibronectin level of homogenized kidney tissue decreased dose-dependently in diabetic mice treated with glycyrrhizin (p<0.05). Our study supports that the antiinflammatory and antioxidative effects of glycyrrhizin on STZ-induced diabetic mice. It also shows that glycyrrhizin may have the ability to prevent kidney from fibronectin accumulation.