Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Monomers and Dimers as Antitumor Alkylation agents
碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 96 === Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are natural products from many kinds of Streptomyces, and exhibited high bioactivities of antibiotics and antitumors in past reports. In the minor groove of DNA, an aminal bond is formed through nucleophilic attack of...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/49118971035827749783 |