Mechanism of CYP3A4 inhibition by antifungal azole compounds
碩士 === 國立成功大學 === 藥理學研究所 === 96 === Pregnane X receptor (PXR) functions as a xenobiotic sensor which recruit transcriptional coactivators such as steroid receptor coactivator-1 (SRC-1) upon ligand binding, and therefore induces genes involves in drug metabolism and disposition, such as CYP3A4 enzyme...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/01804253562164375454 |