Molecular Dynamics Simulations to Investigate the Relationships between the Structural Stability and Amyloidosis of the Wild-type and N-terminal Hexapeptide Deletion △N6 β2-Microglobulin and Its K3 Peptide Oligomers
碩士 === 國立臺北科技大學 === 生物科技研究所 === 96 === β2-Microglobulin (β2m) forms amyloid fibrils in patients undergoing long-term hemodialysis, leading to dialysis-related amyloidosis (DRA). Proteolysis of the N-terminal region of β2m results in a truncation of the six N-terminal residues (△N6 β2m) in ~30% of th...
| Main Authors: | , |
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| Format: | Others |
| Language: | en_US |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/9m9b27 |