Synthesis and Pharmacological Evaluation of N-Substituted Arylsulfonamide Derivatives asNew γ-Secretase Inhibitors

碩士 === 國防醫學院 === 藥學研究所 === 99 === Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disease characterized by beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) formation. The overproduction and accumulation of Aβ are key pathogenic events in AD progression. Aβ i...

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Bibliographic Details
Main Authors: Chen, Chia-Yu, 陳佳瑜
Other Authors: Hu, Ming-Kuan
Format: Others
Language:zh-TW
Published: 2011
Online Access:http://ndltd.ncl.edu.tw/handle/00797993498231743572