Human ABCB1 (P-glycoprotein/MDR1) and ABCG2 (BCRP/MXR) Mediate Resistance to Polo-like kinase 1 inhibitors

Human ABCB1 (P-glycoprotein/MDR1) and ABCG2 (BCRP/MXR) Mediate Resistance to Polo-like kinase 1 inhibitors

碩士 === 長庚大學 === 生物醫學研究所 === 102 === The overexpression of the serine/threonine specific polo-like kinase 1 (Plk1) has been detected in various types of cancer, and thus has fast become an attractive therapeutic target for cancer therapy. Plk1 inhibitors BI 2536, volasertib and GSK461364, were design...

Full description

Bibliographic Details
Main Authors:	Shi Yu Luo, 羅仕瑜
Other Authors:	C. P. Wu
Format:	Others
Published:	2014
Online Access:	http://ndltd.ncl.edu.tw/handle/48402034791397339617

Similar Items

The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells
by: Wang Yin, et al.
Published: (2021-05-01)

Hedgehog Pathway Inhibitor HhAntag691 Is a Potent Inhibitor of ABCG2/BCRP and ABCB1/Pgp
by: Yimao Zhang, et al.
Published: (2009-01-01)

Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)
by: Englund, Gunilla
Published: (2005)

Substrate specificities of the human ABC transporters ABCG1 and BCRP
by: Janvilisri, Tavan
Published: (2005)

CORRELATION BETWEEN CHEMOTHERAPY RESPONSE AND EXPRESSION PROFILES OF TRANSMEMBRANE PROTEINS: P-GLYCOPROTEIN (ABCB1), MRP2 (ABCC2), BCRP (ABCG2) IN PATIENTS WITH INVASIVE BREAST CANCER
by: К. Yu. Khristenko, et al.
Published: (2016-10-01)

Karanjin interferes with ABCB1, ABCC1, and ABCG2
by: Martin Michaelis, et al.
Published: (2014-03-01)

Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging
by: Israa eAbdelrahman, et al.
Published: (2014-11-01)

Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
by: Anja Brenn, et al.
Published: (2011-01-01)

Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice
by: Sparreboom Alex, et al.
Published: (2009-07-01)

Synthesis of imidazole analogs as ABCB1/ABCG2 inhibitors and the study of their structure-activity relationship
by: LI,HAI-CHEN, et al.
Published: (2016)

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1).
by: Jakub Hofman, et al.
Published: (2013-01-01)

Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
by: Krupa S. Jani, et al.
Published: (2012-02-01)

Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
by: Krupa S. Jani, et al.
Published: (2012-01-01)

The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer
by: Beata Mrozikiewicz-Rakowska, et al.
Published: (2017-09-01)

Linear Regression QSAR Models for Polo-Like Kinase-1 Inhibitors
by: Pablo R. Duchowicz
Published: (2018-02-01)

Expression of ABCG2 (BCRP) in mouse models with enhanced erythropoiesis
by: Gladys Oluyemisi Latunde-Dada, et al.
Published: (2014-06-01)

In silico design of potential modulators of ABCB1 and ABCG2 transport activity
by: Mares-Samano, Sergio
Published: (2010)

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
by: Cara Andrea, et al.
Published: (2007-03-01)

The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.
by: Pei-Rong Ding, et al.
Published: (2011-04-01)

Investigating the nucleotide-binding domains of Abcb1a (mouse P-glycoproteinMdr3) : a mutational analysis approach
by: Carrier, Isabelle, 1976 Dec. 18-
Published: (2008)

A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening
by: Sara Abdelfatah, et al.
Published: (2019-03-01)

BCRP/ABCG2 inhibition sensitizes hepatocellular carcinoma cells to sorafenib.
by: Wei-Chien Huang, et al.
Published: (2013-01-01)

The CINs of Polo-Like Kinase 1 in Cancer
by: Chelsea E. Cunningham, et al.
Published: (2020-10-01)

The balance of Polo-like kinase 1 in tumorigenesis
by: Yu Xiaochun, et al.
Published: (2009-01-01)

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure
by: Myriam El Biali, et al.
Published: (2021-06-01)

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2
by: Mark C. de Gooijer, et al.
Published: (2018-07-01)

Super analgesia of intrathecal morphine may be related to ABCB1 (MDR1) gene polymorphism
by: Qin WJ, et al.
Published: (2018-07-01)

Investigating the interactions of MY-5445, a PDE5 inhibitor, and LY3023414, a PI3K/mTOR dual inhibitor, with MDR-linked ATP-binding cassette proteins ABCB1 and ABCG2
by: Pin Jung Tseng, et al.
Published: (2019)

SBE13, a newly identified inhibitor of inactive polo-like kinase 1
by: Keppner Sarah, et al.
Published: (2010-05-01)

Polo-like kinase 1 modulated by HDAC inhibitors treatment in gastric cancer cells
by: Nai-Jung Yen, et al.
Published: (2008)

Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat
by: Chung-Pu Wu, et al.
Published: (2021-03-01)

Effects of α-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport.
by: Kohji Takara, et al.
Published: (2012-01-01)

Gene and functional up-regulation of the BCRP/ABCG2 transporter in hepatocellular carcinoma
by: Sukowati Caecilia HC, et al.
Published: (2012-11-01)

BCRP (ABCG2) expression, function and regulation in model and intestinal epithelial cells
by: Wright, Jamie Andrew
Published: (2011)

Enhancement of Pichia pastoris AOX1 Promoter Efficiency by Reprogramming the Transcription Factor Mxr1
by: Ching-Hsiang Chang, et al.
Published: (2017)

Polo-like kinase 1 as target for cancer therapy
by: Weiß Lily, et al.
Published: (2012-12-01)

Targeting MDR1-P-glycoprotein (MDR1-Pgp) in immunochemotherapy of acute myeloid leukemia (AML)
by: Maurizio Cianfriglia
Published: (2013-06-01)

Development of Highly Selective 1,2,3-Triazole-containing Peptidic Polo-like Kinase 1 Polo-box Domain-binding Inhibitors
by: Xue Zhi Zhao, et al.
Published: (2019-04-01)

Renal Ontogeny of P-Glycoprotein/MDR1 in Rat
by: Hodorova I., et al.
Published: (2011-03-01)

ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells
by: Changfu Liu, et al.
Published: (2021-02-01)