Mechanistic and biological significance on ABT-199-induced MCL-1 up-regulation in human colon cancer cell lines
碩士 === 國立中興大學 === 生物醫學研究所 === 103 === ABT-199 is a BH3 mimetic derived from navitoclax (ABT-263). ABT-199 inhibits the anti-apoptotic activity of Bcl-2, but not BCL-xL and MCL-1. MCL-1 is an anti-apoptotic Bcl-2 family protein. Overexpression of MCL-1 causes cancer cell evasion of apoptosis and in...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/84216042279268554346 |