Molecular Dynamic Simulation to Survey Possible Resistance Mechanisms of ALK Inhibitors to G1202R Mutation in EML4-ALK Translocation Positive Non-small Cell Lung Cancer
碩士 === 國立中山大學 === 醫學科技研究所 === 106 === Non-small cell lung cancers (NSCLC) with ALK rearrangements are highly sensitive to ALK tyrosine kinase inhibition (TKI). The multi-targeted TKI crizotinib, ceritinib, alectinib, and brigatinib have been approved by the U.S. food and drug administration (FDA) in...
| Main Authors: | , |
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2018
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| Online Access: | http://ndltd.ncl.edu.tw/handle/cx98db |