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碩士 === 國立中央大學 === 統計研究所 === 107 === In this thesis, a two-stage robust design is proposed to find the optimal biological dose (OBD) of a molecular targeted agent (MTA) in an early clinical trial. In the first stage, any model-free design can be used to estimate the maximum toxicity dose (MTD) so tha...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2019
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| Online Access: | http://ndltd.ncl.edu.tw/handle/8jhte9 |