Synthesis on solid phase of a bicyclic octapeptide amatoxin
The α-amanitin is an excellent template for use in the design of a chemical library on solid phase in order to study the mechanisms involved in the regulation of transcription. Indeed, α-amanitin selectively inhibits with high affinity the RNA Polymerase II. The α-amanitin belongs to the amatoxin fa...
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| Format: | Others |
| Language: | English |
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University of British Columbia
2009
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| Online Access: | http://hdl.handle.net/2429/12343 |