Progranulin (PGRN) functions in neuronal cultures
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotemporal lobe dementia with ubiquitinated inclusions (FTLD-U). In this disorder, the ubiquitinated aggregated protein inclusions of a normally nuclear-located RNA processing protein called TAR DNA binding pr...
| Main Author: | |
|---|---|
| Format: | Others |
| Language: | English |
| Published: |
University of British Columbia
2009
|
| Online Access: | http://hdl.handle.net/2429/12702 |