Targeting Akt signaling in breast cancer : expression of phosphorylated Akt in breast tumors and the efficacy of celecoxib analogues as potential inhibitors of Akt activation
Constitutive activation of Akt, due to overexpression of receptor tyrosine kinases (RTKs) or loss of phosphatase and tensin homologue (PTEN), contributes to the development of breast cancer and confers resistance to conventional therapies. Therefore, the Akt signaling pathway is an attractive tar...
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| Format: | Others |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/2429/16264 |