Striatal neuronal apoptosis is preferentially enhanced by N-methyl-D-aspartate receptor activation in a YAC transgenic mouse model of huntington's disease
Huntington's disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamine (polyQ) repeats in the huntington gene affecting medium spiny neurons (MSNs) of the striatum. One hypothesis put forward to explain neuronal degeneration in HD is that glutamate excitotoxicity r...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/16461 |