Maternal and fetal methionine metabolism and the implications on programming of the hypothalamic pituitary adrenal axis by prenatal alcohol exposure
Chronic ethanol exposure is known to disrupt the methionine cycle in liver of adult rats. Alterations in the methionine cycle are associated with changes in tissue methylation capacity and may affect DNA and histone methylation thereby altering epigenetic regulation of gene expression, causing long-...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/22433 |