Pharmacokinetic and metabolism studies of valproic acid using gas chromatography mass spectrometry
Di-(3-²H₃-propyl)acetic acid was synthesized and used in pharmacokinetic and metabolism studies of dipropyl acetic acid (valproic acid). Kinetic equivalence of valproic acid and valproic acid-²Hg₆ was demonstrated in a single dose study in a human volunteer. An isotope effect was observed for w-...
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| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/2429/22938 |