Targeting the tumour microenvironment : characterizing the anti-vascular effects of the hypoxic cytotoxin tirapazamine
Tirapazamine (TPZ) is a bioreductive prodrug with greater toxicity to hypoxic cells in vitro, and anti-vascular activity in tumours grown in vivo in mice. Considerable inter- and intra-tumour heterogeneity occurs in response to the anti-vascular effects of TPZ. The main hypothesis for the work descr...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/23242 |