Mechanistic studies and manipulation of the enzymes in sialic acid and pseudaminic acid biosynthesis
The Neisseria meningitidis sialic acid synthase (NeuB) catalyzes the metal-dependent condensation of N-acetylmannosamine (ManNAc) and phosphoenolpyruvate (PEP) to generate N-acetylneuraminic acid. This work describes the synthesis and characterization of the first potent inhibitor of sialic acid syn...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/24013 |