Cellular abnormalities seen in the autoimmune MRL-lpr mouse strain
The MRL-+ and MRL-/pr mouse strains spontaneously develop autoimmune disease similar to human SLE. The autosomal recessive Ipr gene causes extensive lymphoproliferation of a unique DN T cell. The transfer of the Ipr gene to non-autoimmune mice [B6- lpr] has revealed other functions of the Ipr gene,...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/27494 |