Synthesis and conformational studies of 10, 10-dimethyltridecanolide
The synthesis of 10,10-dimethyltridecanolide (42) was achieved via a fifteen-step sequence in 9% overall yield. The hydrolysis of macrolides 42, 35, and ester 109 was used to probe the conformational behavior of macrolide 42. The results of this study were rationalized through molecular mechanics (...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/27960 |