Selective cleavage of transfer ribonucleic acid
All guanosine residues in tRNA react with glyoxal to form adducts. No breakage of phosphodiester bonds of the tRNA occurs during the reaction. These adducts contain vicinal hydroxyl functions which can complex with borate or be oxidized by periodate to give N-formyl guanosine residues. The latter in...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/36830 |